Put players at 1st, 2nd, Center field, Right Field, Pitcher and Catcher. Have the rest of the team put helmets on, and line up at first base. The first runner gets ready on first. The pitcher pitches the ball and the runner takes a lead. The catcher attempts a pick-off at first and the runner tries to get back in time. On the next pitch the runner attempts to steal second and the catcher tries to throw her out. Make sure the Center fielder and Right fielder back up 2nd base and 1st base respectively.
The drill gives the catcher a lot of practice throwing to the bases, allows the fielders to practice positioning themselves for and putting on the tag, and allows the base runners a chance to practice leading off and sliding.